WS Biotin™ is water-soluble D-Biotin (50% w/w, 2.2g/100ml) for hair care; at 0.1% it upregulated FGF7 hair-growth gene expression by 122.1% in vitro.
WS Biotin™ for Hair Care: At Last, an Easy Way to Design Highly Concentrated, Effective D-Biotin Formulations
D-Biotin and Its Formulation Challenges
Biotin is a common supplement, also known as vitamin B7. It plays a critical role in a handful of metabolic processes in our body. More specifically, it stimulates keratin growth, which is responsible for healthy hair, nails, and skin. Biotin has been promoted as a means for improving hair health and as an essential ingredient for healthy looking hair. It is often touted as a miracle ingredient that increases hair's shine and volume while strengthening hair follicles and preventing loss.
Biotin occurs as a practically white, crystalline powder with very slight solubility in water, alcohol and other common organic solvents. Therefore, there is a real need to increase its water solubility to overcome this formulation challenge, allowing the design and development of effective hair products.
Tagra's Solution
To improve D-Biotin's effectiveness in hair care formulations, Tagra has developed a groundbreaking, innovative solution: WS Biotin™. It is a water-soluble, dry powder form of D-Biotin (50% w/w), offering a higher solubility level of 2.2g/100ml compared to 0.02g/100ml for free D-Biotin. Tagra's unique technology leads to a significant increase in aqueous solubility without high-energy investment, showing WS Biotin™ to be highly useful.
How Do We Know It Works?
The in vitro treatment with 0.1% of WS Biotin™ water solution in Human Follicle Dermal Papilla Cells (HFDPC) displays hair growth-stimulating effects, substantiated in a significant upregulation of Fibroblast Growth Factor 7 (FGF7) compared to the untreated control.
In-vitro assay results for stimulating the gene expression of FGF7 (Control, 0.01%, 0.1%) show that treatment with WS Biotin™ at 0.1% significantly upregulated gene expression by 122.1% versus untreated control.
How to Formulate with WS Biotin™
WS Biotin™ is a pertinent solution for haircare (shampoos, conditioners, serums, aerosol) products. Formulating with WS Biotin™ results in a pH of 6-7 and does not require using any organic solvents for solubilizing D-Biotin. It prevents any risk of crystallization in the formula, and it is added to the formulation at room temperature. No mixing process is required as WS Biotin™ is solubilized spontaneously.
Water Solubility of WS Biotin™ in Comparison to Free Biotin
Left: WS Biotin™ water solution at 4% (equivalent to 2% free D-Biotin) after 30 days incubation at 10°C.
Right: 0.1% water solution of free D-Biotin after 24h incubation at 10°C.
Crystals were formed in the free D-Biotin solution while no crystals were formed in the WS Biotin™ water solution.
Technical Data
INCI | D-Biotin & Caprylic Acid & Polyvinylpyrrolidone |
|---|---|
Payload | ~50% D-Biotin |
Appearance | Powder |
Color | White |
Recommended usage level | 1.2% |
Storage conditions | Closed container at ambient temperature |
WS Biotin™ is globally approved including China, non-GMO and is BSE, Halal, and vegan compliant.
Request a sample of the Tagra ingredients in this formula at tagra.com/engine.
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